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phase increases in plasma fibrinogen concentration and viscosity. In particular, however, we found that the filterability of both polymorphonuclear and mononuclear leucocytes is reduced in acute cerebral infarction. This may not only explain the reduced filterability of blood but also promote malperfusion of the microcirculation and infarction. Reduced filterability of leucocytes may be part of the acute phase response to injury, as suggested by the correlation with fibrinogen concentration in the patients with stroke and by similar findings in the controls with chest infection. Preceding infection is an important risk factor for cerebral infarction.5 The risk of infarction also increases with age, and we observed decreased filterability of leucocytes in controls aged over 40. We suggest that mechanisms by which increasing age and infections increase the risk of cerebral infarction include increased plasma fibrinogen concentration and viscosity and decreased filterability of leucocytes, each of which tends to reduce capillary flow.